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  Retrotransposons in immunity


   School of Biotechnology and Biomolecular Sciences

   Applications accepted all year round  Competition Funded PhD Project (Students Worldwide)

About the Project

Only about 1-2% of our genome is made up of protein coding genes, the rest is non-coding and at least half of that is made up of repetitive DNA sequences known as transposable elements (TEs). TE sequences are information rich; harbouring promoters, enhancers and transcription factor binding sites. However, research is only just beginning to uncover potential mechanisms by which TEs regulate genes and gene networks. This project is focused on understanding the function of class I TEs known as retrotransposons during the highly tractable immune response. To do this, you will have the opportunity to study selected TEs, utilize unique TE knockout mouse models and TE CRISPR/Cas9 libraries, and use cellular and molecular approaches coupled with sequencing analyses to create a comprehensive picture of how TEs influence gene transcription and cell phenotype during the immune response.

Ideally, we are seeking a candidate with prior research experience, proficiency in cellular and molecular biology, and knowledge of at least one computational language (e.g., Python, R) would be an advantage.

Interested candidates, please email a cover letter explaining your interest in the position and relevant experience along with a CV and transcripts to .

Biological Sciences (4)

Funding Notes

PhD scholarships are awarded on a competitive basis by UNSW Sydney (View Website).

References

https://www.unsw.edu.au/staff/cecile-king

Register your interest for this project


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