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Reversing multidrug chemoresistance in head and neck cancer


   Institute of Dentistry

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  Dr M T Teh  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Background:
Multidrug resistance renders chemotherapeutic treatment failure in large proportion of head and neck squamous cell carcinoma (HNSCC) patients requiring multimodal therapy involving chemotherapy in conjunction with surgery and/or radiotherapy. Molecular events conferring chemoresistance remain unclear. This project investigates a number of chemical, biological and physical strategies for targeting molecular vulnerabilities of chemoresistant cancer cells whilst sparing non-cancer cells. A large panel of chemical library consisting of synthetic and natural compounds will be screened using human cell culture models.

Aims:
This project aims to identify the most potent multimodal anticancer therapy with the least toxicity to prevent or reverse chemoresistance in HNSCC patients.

How to apply
For more information regarding the project, please contact Dr Muy-Teck Teh ([Email Address Removed])

Applications should be submitted through the Queen Mary application system. Please indicate the project title and supervisor in the ‘Research Degree Programmes - Additional Questions’ section of the application.

Alongside the application form, please send the following supporting documents:
• Curriculum Vitae (CV)
• Copies of your degree certificates with transcripts
• Proof of English language ability for overseas applicants from non-English speaking countries
• A one-side A4 statement of purpose. This should set out your previous academic or other experience relevant to the proposed research; why you wish to undertake this research at QMUL; your previous research or professional training and what further training you think you will need to complete a PhD; and what ethical issues you will need to consider in undertaking this research.
• Two references. At least one reference must be from an academic referee who is in a position to comment on the standard of your academic work and suitability for postgraduate level study. Where appropriate, a second referee can provide comment on your professional experience.

Please contact the PGR Administrator on ([Email Address Removed]) with any queries about the application process.

Funding Notes

Person specification:
A graduate with at least an upper second class honours degree or a distinction in an experimental MSc degree is required for this PhD project. The candidate should have strong interests and preferably with some experience in cell and molecular biology, pharmacology, biochemistry or biomedical science.

Funding notes:
We will consider applications from prospective students with funding to cover fees for three years full-time or 6 years part-time. Both self-funded and sponsored students will be considered.

UK and EU students might be eligible for the cost of tuition fees and a stipend from Student Finance England: https://www.gov.uk/doctoral-loan
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