About the Project
In many tissues, circadian clock genes (the machinery that drives the clock) are closely connected to metabolic pathways. Importantly this connection is reciprocal, meaning that the clock not only drives the rhythmic activity of key metabolic genes, but is itself strongly influenced by metabolism and cellular energy status. For example, when nocturnal laboratory mice are forced to feed only during the day, many aspects of their physiology become disconnected from the SCN, which remains locked to environmental light cycles. Thus, the strong influence of diet and eating behaviour on circadian clocks suggests that abnormal energy supply (over consumption of high-calorie foods, or disordered eating habits) will be effective at dampening circadian control of metabolism. This raises three important questions: 1) are some of our body clocks particularly susceptible to diet-induced disruption; 2) how does the loss of clock function within these ’susceptible’ clocks impact on overall metabolic or behavioural rhythms; 3) what critical components form the clock-metabolic interface in such tissues. We welcome applications from students wishing to examine these questions.
As an equal opportunities institution we welcome applicants from all sections of the community regardless of gender, ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.
Informal enquiries may be made directly to the primary supervisor.
Li J, Hand LE, Meng QJ, Loudon AS, Bechtold DA (2011) GPR50 Interacts with TIP60 to Modulate Glucocorticoid Receptor Signalling. PLoS One 6(8):e23725.
Bechtold DA, Gibbs JE, Loudon AS. (2010) Circadian dysfunction in disease. Trends Pharmacol Sci 31(5):191-8.
Meng QJ*, Maywood ES*, Bechtold DA*, Lu WQ, Li J, Gibbs JE, Chesham J, Rajamohan F, Knafels F, Ohren JF, Walton KM, Wager TT, Hastings MH, Loudon AS. (2010) Entrainment of disrupted circadian behavior through inhibition of CK1 enzymes. PNAS 107(34):15240-5
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