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RNA biology and protein synthesis in neurodegeneration (Berlin, Germany)

   Medical Systems Biology

  Dr Marina Chekulaeva  Applications accepted all year round  Funded PhD Project (Students Worldwide)

About the Project

Motor neuron disorders (MNDs) are a group of neurodegenerative diseases affecting motor neurons, i.e. neurons that control skeletal muscle contraction to produce motion. The project aims to investigate how changes in RNA metabolism contribute to the mechanism of neurodegeneration. The successful candidate will apply a combination of systems biology, biochemical, and imaging approaches (e.g., Ribo-seq, CLIP-seq, CRISPR-mediated gene editing, etc.), including a compartmentalized neuronal culture (Zappulo et al. 2017; Ludwik et al. 2019; Ciolli et al. 2019; von Kuegelgen et al. 2021) in hiPSC-based differentiation systems. For more details, see http://www.chekulaevalab.org.

The ideal candidate should have a Master's degree in biology, biochemistry, or molecular biology, experience in molecular biology techniques and cell culture, interest in RNA biology and mechanisms of gene regulation, and speak fluent English. Experience in hiPSC work and RNA biology techniques is an advantage. To apply, please send your motivation letter and CV with contact details of at least two referees to marina.chekulaeva(at)mdc-berlin.de


Recommended reading:
(1) von Kuegelgen et al. bioRxiv (2021); (2) Mendonsa et al. NAR (2021); (3) Ciolli Mattioli et al. NAR (2019); (4) Zappulo et al. Nature Comm (2017)

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