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RNA transport in angiogenesis: deciphering mechanisms of RNA localisation to understand blood vessel growth

  • Full or part time
  • Application Deadline
    Monday, January 20, 2020
  • Funded PhD Project (European/UK Students Only)
    Funded PhD Project (European/UK Students Only)

Project Description

Angiogenesis, or the emergence of new blood vessels, is a complex biological process that involves the coordinated migration of endothelial cells. Critical guidance cues secreted by the surrounding tissues regulate the molecular and cellular responses triggered during angiogenesis. Although the subcellular localisation of RNAs is a well-established mechanism underpinning cell migration, how RNAs are targeted to particular cell compartments in motile endothelial cells during blood vessel formation is not known.

This PhD project aims to 1) explore the role of RNA binding proteins (RBPs) present at the leading edge of endothelial cells and 2) shed light on the signalling machinery that modulates RBP targeting in the context of angiogenesis. The localised activity of RBPs at the endothelial cell front will be studied using in vitro models of angiogenesis to demonstrate the relevance of RNA localisation in sprouting vessels. In addition, how the Vascular Endothelial Growth Factor signalling pathway may stimulate RBP localisation during vessel guidance and growth will also be investigated. Altogether, the studies proposed in this project will contribute to further understanding of mechanisms of blood vessel formation and provide a novel avenue in the pursuit for angiogenesis-related therapies.

ENTRY REQUIREMENTS

Candidates should have or expect to obtain a 2:1 or higher Honours degree or equivalent in a relevant biomedical or life sciences subject.

English Language

Candidates applying from countries where the first language is not English should produce evidence of their competence through a qualification such as IELTS or TOEFL score.

The minimum recommended score for the School of Medicine, Dentistry and Biomedical Science is:
• IELTS score of 6.0 with not less than 5.5 in each of the four component elements of listening, reading, speaking and writing taken within the last 2 years;
• TOEFL score of 80+ (internet basted test), taken within the last 2 years, with minimum component scores of; Listening 17, Reading 18, Speaking 20, Writing 17);
• A valid Certificate of Proficiency in English grade A or B;
• A valid Certificate of Advanced English grade A; or
• A first or upper second class honours degree from a university based in the UK, Republic of Ireland or other suitably quality assured location in a country deemed by the UK Border Agency to be majority English speaking.

For a list of English Language qualifications also accepted by the School and University please see the following link:
http://www.qub.ac.uk/International/International-students/Applying/English-language-requirements/#English

INTO Queen’s English Language Courses offers both pre-sessional and in-sessional courses in English for academic purposes and study skills. Courses vary in length and full information can be obtained at: https://www.qub.ac.uk/International/International-students/Applying/University-Preparation-Courses/INTOEnglishlanguagecoursesatQueens/

Funding Notes

*FUNDING CONFIRMED – Department for the Economy (DfE) Award*

Eligibility for both fees (£4,327 for 2019/20, 2020/21 TBC) and maintenance (£15,009 for 2019/20, 2020/21 TBC) depends on the applicants being either an ordinary UK resident or those EU residents who have lived permanently in the UK for the 3 years immediately preceding the start of the studentship.

Non UK residents who hold EU residency may also apply but if successful may receive fees only.

For further details re eligibility criteria (including academic, citizenship and residency criteria) please click on the following link: View Website

References

Please visit the School of Medicine, Dentistry and Biomedical Sciences, Centre for Experimental Medicine, website for further details about the Centre:

http://www.qub.ac.uk/research-centres/CEM/

When applying, please choose 'MEDICINE' as your subject area/School.

Related Subjects

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