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Role, biogenesis, and biodegradation of NpnN RNA caps in prokaryotes

  • Full or part time
    Dr H Cahová
  • Application Deadline
    Sunday, February 23, 2020
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Recent discovery of RNA caps such as NAD and CoA leads to reassessment of RNA structure in all types of cells. In our search for new RNA modifications, we have discovered brand new class of 5‘caps – dinucleoside polyphosphates (NpnN) in bacteria. So far, we have not identified methyltransferases that methylate them. We do not know what regulates their incorporation into RNA, what RNA are capped with NpnNs and what is the role of NpnN caps. The task of the thesis is to reveal the role, biogenesis and biodegradation of these new caps.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2020”:
https://www.uochb.cz/en/phd-program

If you decided to apply, please do so online via our application form:
https://www.uochb.cz/en/call-for-phd-applications

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

Chen, Y. et al. LC/MS analysis of cellular RNA reveals NAD-linked RNA. Nat. Chem. Biol. 5, 879 (2009).

Cahová, H. et al. NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs. Nature, 519, 374 (2015).

Hudeček, O., et al. Dinucleoside polyphosphates act as 5’-RNA caps in bacteria bioRxiv doi: https://doi.org/10.1101/563817 (under revision Nature Comm.)

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