About the Project
For instance, data to date indicate that biofilm carbohydrates induce phenotypical changes in monocyte-derived dendritic cells, but we still do not know the biological consequences of these changes. We will explore this aspect by looking at dendritic cell-T cell co-cultures and dendritic cell migration. Analysis of macrophage and monocyte behaviour will include cytokine production, changes in gene expression and microbicidal activity against P. aeruginosa. A second aspect of the project will explore the potential role of biofilm carbohydrates in modulating the response of macrophages, dendritic cells and monocytes to the fungal pathogen C. albicans.
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