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Role of cell death and necroinflammation in pulpal wound healing


   School of Medicine, Dentistry & Biomedical Sciences

  Dr I El Karim  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Injury to the dental pulp is commonly encountered in clinical practice, but how injury induce inflammation and how the dental pulp heals after injury is not known. This project will specifically look at sterile inflammation signalling pathways in injured pulp to identify potential diagnostic and therapeutic targets for pulpitis.

Cell death following injury to the dental pulp lead to sterile inflammatory response (Necroinflammation) that is critical for healing and repair. The aim of this project is to investigate the signalling pathways associated with sterile necroinflammation that activate local stem cells and initiation of the repair process. The study will employ various laboratory techniques and ex-vivo models

Start Date: October 2022


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