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Role of centriolar proteins in invasion


   Biosciences

   Applications accepted all year round  Funded PhD Project (European/UK Students Only)

About the Project

Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer remains unclear. Centriole and cilia defects have been shown to be characteristic of breast cancers and to regulate cancer cell invasion. However, how ciliary signalling affects cancer survival and cell invasion is not known.

Using a number of cell lines generated in our laboratory, we will examine how centriole and cilia proteins regulate invasion in both normal and cancer cells. We will use biochemical, cell biology, molecular biology and cancer biology techniques. We will carry out western blots, invasion and proliferation assays. We will collaborate with cancer biologists, bioinformaticians and a number of laboratories in the UK and abroad.

Applicants for this project should be enthusiastic about science and willing to learn a number of new techniques.

This is a partially funded PhD. Students will get their first-year fees covered to the value of Home/EU fees, plus the benchmark fees will be funded too.

Funding Notes

This is a partially funded PhD. Students will get their first-year fees covered to the value of Home/EU fees, plus the benchmark fees will be funded too. Students will need to cover the remaining fees for the remaining years.

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