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Role of centriolar proteins in invasion


   Biosciences

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  Dr B Tanos  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including Smoothened, KRAS, EGFR, and PDGFR), their precise role in cancer remains unclear. Centriole and cilia defects have been shown to be characteristic of breast cancers and to regulate cancer cell invasion. However, how ciliary signalling affects cancer survival and cell invasion is not known.

Using a number of cell lines generated in our laboratory, we will examine how centriole and cilia proteins regulate invasion in both normal and cancer cells. We will use biochemical, cell biology, molecular biology and cancer biology techniques. We will carry out western blots, invasion and proliferation assays. We will collaborate with cancer biologists, bioinformaticians and a number of laboratories in the UK and abroad.

Applicants for this project should be enthusiastic about science and willing to learn a number of new techniques.


Funding Notes

Brunel offers a number of funding options to research students that help cover the cost of their tuition fees, contribute to living expenses or both. See more information here: https://www.brunel.ac.uk/research/Research-degrees/Research-degree-funding. The UK Government is also offering Doctoral Student Loans for eligible students, and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.

How good is research at Brunel University London in Allied Health Professions, Dentistry, Nursing and Pharmacy?


Research output data provided by the Research Excellence Framework (REF)

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