The project: T-cell-based immunotherapies are highly successful in reducing or eliminating melanoma in some patients, but still most patients have little or no response. This project aims to identify ways to enhance T-cell recruitment to melanoma, which could improve patient outcome. T-cells enter cancers by migrating across the endothelial cells lining blood vessels. We have found that Eph receptor tyrosine kinases and their Ephrin ligands can promote T-cell attachment to endothelial cells. The project will determine which Eph/Ephrin pairs are important for this process and hence for recruiting different types of T-cells into melanomas.