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Role of Eph tyrosine kinases in cancer immunotherapy

  • Full or part time
  • Application Deadline
    Monday, November 25, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

The project: T-cell-based immunotherapies are highly successful in reducing or eliminating melanoma in some patients, but still most patients have little or no response. This project aims to identify ways to enhance T-cell recruitment to melanoma, which could improve patient outcome. T-cells enter cancers by migrating across the endothelial cells lining blood vessels. We have found that Eph receptor tyrosine kinases and their Ephrin ligands can promote T-cell attachment to endothelial cells. The project will determine which Eph/Ephrin pairs are important for this process and hence for recruiting different types of T-cells into melanomas.

How to apply: https://www.gw4biomed.ac.uk/doctoral-students/
This project is being advertised as part of a competition for GW4 BioMed Medical Research Council (MRC) funded projects (https://www.gw4biomed.ac.uk), where 18 studentships are available. Studentships will be allocated to the highest quality candidates. Applications can be submitted, and further information found by following the link below:
https://www.gw4biomed.ac.uk/doctoral-students/

Funding Notes

GW4 BioMed MRC Doctoral Training Partnership.

This is a fully funded PhD.

Related Subjects

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