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Role of Hormones and Load on Trabecular and Cortical Bone Remodelling

Project Description

Faculty of Health & Wellbeing, Sheffield Hallam University
Biomolecular Sciences Research Centre
PhD Research Studentship (full-time for 3 years)
Stipend: £14,777 per annum

A three-year PhD studentship is available to UK and EU students. The studentship covers home/EU tuition fees, stipend equivalent to full UK Research Council rate and research expenses.

Currently, over 60% of the UK population is categorised as overweight or obese. However, the underlying effects that excess adipose tissue may have on bone health and remodelling are not yet fully understood. Factors influencing discrepancies include the contribution of load, hormones, gender, age, experimental model, bone type and region investigated. Identifying the independent or synergistic role these factors may play in bone health and remodelling will be important when considering the implications on an ageing population, the majority of which have been overweight/obese in their lifetime.

The successful candidate will use a variety of in vitro and ex vivo bone tissue/cell samples to determine the role of specific obesity hormones and load on bone remodelling parameters.

The successful candidate will be trained in and gain high-level experience of:
• In vitro cell culture and ex vivo tissue processing.
• Biomechanical cell loading equipment.
• Histology and immunohistochemistry.
• µCT scanning, image reconstruction and analysis including densitometry and morphometry.
• Experimental study design, scientific writing and presentation skills.

This project will allow the successful candidate to work in a multidisciplinary research environment incorporating biomechanics and state of the art computer tomography with cell/molecular biology and physiology.

The successful candidate should have (or expect) an honours degree at upper second class (2:1) or above in biology, human biology, biochemistry or a closely related discipline.

A solid background in cell biology/biochemistry is essential and prior experience of tissue processing/histology would be beneficial.

Funding Notes

Candidates should apply to SHU via the University application form, including a 1500 word research proposal demonstrating your background reading on the topic of the PhD and your plans for how you would undertake this programme.

Include a cover letter describing why you are interested in pursuing postgraduate studies and how you meet the selection criteria. Completed application forms to

Application forms can be downloaded at:

View Website

For project enquiries contact

Key Dates:
• Deadline for applications - 29th April 2019
• Interviews will be held 20th - 31st May 2019
• Studentship to begin in October 2019

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