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Role of primary cilia in skeletal muscle stem cells and muscle regeneration.


   School of Biosciences

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  Dr A G Borycki  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. The importance of primary cilia is underscored by the growing family of diseases associated with defects in cilia function, known as ciliopathies. Our laboratory focuses on the study of tissue regeneration following injury and disease, and in aging. We are particularly interested in understanding how primary cilia control the activity of stem cells that reside within our skeletal muscle. We have previously established that primary cilia are key players in the regulation of cell signalling pathways and skeletal muscle stem cell biology. However, the precise mechanisms by which primary cilia control muscle regeneration remains to be elucidated. This project will use the power of mouse genetic models allowing us to selectively eliminate primary cilia in skeletal muscle stem cells, combined with a well-established ex-vivo culture system of skeletal muscle fibres, imaging and genome-wide transcriptomics approaches to investigate the mechanism by which primary cilia control skeletal muscle stem cells, muscle regeneration, and aging.

Science Graduate School

As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience the breadth of technologies that are used in academia, industry and many related careers. Visit www.sheffield.ac.uk/sgs to learn more.


Funding Notes

This position is for self funded or externally funded students only.

First class or upper second 2(i) in a relevant subject. To formally apply for a PhD, you must complete the University's application form using the following link: http://www.sheffield.ac.uk/postgraduate/research/apply/applying

All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information.

References

Cruz-Migoni SB, Mohd Imran K, Wahid A, Rahman O, Briscoe J, Borycki AG.
A switch in cilia-mediated Hedgehog signaling controls muscle stem cell
quiescence and cell cycle progression. BioRxiv doi:
https://doi.org/10.1101/2019.12.21.884601
Jaafar Marican NH, Cruz-Migoni SB, Borycki AG (2016). Asymmetric
Distribution of Primary Cilia Allocates Satellite Cells for Self-Renewal. Stem
Cell Reports. 6(6):798-805.
URL: https://www.sheffield.ac.uk/biosciences/people/bms-staff/academic/anne-gaelle-borycki
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