About the Project
In order to fully understand normal, ageing-associated changes, and thus determine what “healthy” and “unhealthy” ageing means, we need to compare saliva composition at an early age a well as in the later stages of life. Currently very little is known about salivary composition in neonates and how this changes through important childhood milestones such as tooth eruption, weaning and childhood dietary changes and with the onset of puberty. Any changes could signal the potential of saliva as a prognostic biomarker for both oral and systemic disease of childhood and development.
Saliva will be collected from children (from birth to puberty), before and after tooth eruption, with and without oral diseases (e.g. caries or mild gum disease as an early example of inflammation). Proteomic and glycomic analyses and an assessment of the oral microbiome will give baseline measurements and will allow us to determine if changes are associated with normal child development and the impact of mild disease. Where appropriate questionnaires will be completed to relate the impact of health and lifestyle on biological changes.
A further very novel field of study which is of great interest to us is the study of exosomes and their potential as a novel source of biomarkers for prognostic/diagnostic markers of both oral and systemic disease, especially cancer. To date the composition of salivary exosomes has not been investigated in young children.
The outcomes from this study will feed into and inform our larger field of study investigating the proteomic, glycomic and microbiome profile of saliva across our lives and in subjects enduring chronic inflammation and infection. This information could lead to the identification of novel biomarkers and potentially early intervention in disease development.
Interested candidates should in the first instance contact (Dr Lynne Bingle [Email Address Removed])
How to apply:
Please complete a University Postgraduate Research Application form available here: www.shef.ac.uk/postgraduate/research/apply
Please clearly state the prospective main supervisor in the respective box and select School of Clinical Dentistry as the department.
This project is open to self-funded or sponsored applicants. Candidates must have a first or upper second class honors degree or significant research experience.
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.