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Secretory pathway dynamics and extracellular matrix assembly.


School of Biochemistry

Monday, December 07, 2020 Competition Funded PhD Project (Students Worldwide)

About the Project

Cells are the fundamental unit of life. The overall aim of our lab is to understand cell function in the context of membrane and cytoskeleton dynamics. A key focus is the secretion and assembly of a functional extracellular matrix (ECM) 1, 2. The lab specialises in the analysis of membrane traffic in mammalian cells. We use high-resolution light and electron microscopy, notably live cell imaging in 3D over time, to examine the organisation and function of the mammalian secretory pathway both in healthy cells and in disease states (for example see 3). The project will develop and use in vitro cell biology to define the impact of perturbing secretory pathway function on the processing and secretion of procollagens and the ultimate composition and assembly of the ECM.

For further information see:
Web: https://cellbiology.blogs.bristol.ac.uk/
Twitter: @David_S_Bristol

Funding Notes

This project is available under the SWBio DTP programme: Link to SWBio DTP website: View Website

DEADLINE FOR APPLICATIONS: Midnight on Monday 7 December 2020

How to apply: View Website

Information on eligibility: View Website

References

1. McCaughey, J., Stevenson, N.L., Cross, S. & Stephens, D.J. ER-to-Golgi trafficking of procollagen in the absence of large carriers. J. Cell Biol. 218, 929-948 (2019).
2. McCaughey, J. & Stephens, D.J. ER-to-Golgi Transport: A Sizeable Problem. Trends Cell Biol 29, 940-953 (2019).
3. Stevenson, N.L., Dylan, J.M.B., Hammond, C.L. & Stephens, D.J. Giantin is required for intracellular N-terminal processing of type I procollagen. bioRxiv, 2020.2005.2025.115279 (2020).

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