About the Project
Electrosynthesis has been widely studied within the electrochemical community and has great potential for the construction of chemical bonds but represents an underused tool. Recently the area has seen a resurgence of interest from synthetic chemists due to the versatility of applications and the possible green credentials of “reagentless” synthesis. Recently we reported the selective hydrocarboxylation of substituted aromatic alkenes utilising electrosynthesis and carbon dioxide. This novel carbon-carbon bond forming process provides unprecedented access to all carbon quaternary centres through the carboxylation of beta,beta-substituted olefins. In a series of preliminary studies, we have also examined the process for the carboxylation of dienes. These promising preliminary findings (& those in Scheme 3) demonstrate the proof-of-principle that selective hydrocarboxylation of a derivative of dehydroalanine (Dha) is possible.
This project will deliver selective functionalization of peptides exploiting our experience in carboxylation/electrosynthesis to novel functionalized peptides under green chemistry protocols for herbicidal, fungicidal or insecticidal applications.
Entry requirementsStudents should have or expect to achieve a minimum of a upper second class BSc or MChem degree or MSc or equivalent qualification
Applicants must meet the minimum English language requirements. Further details are available on the International website: http://www.lboro.ac.uk/international/applicants/english/
How to applyAll applications should be made online: https://www.lboro.ac.uk/study/postgraduate/apply/research-applications/. Under school/department name, select 'Chemistry'. Please quote reference CM/BB-Un2/2021.
J. Am. Chem. Soc. 2020, 142, 1780 & Chem. Sci. 2020 9109
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