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Selectivity of translocation across lipid membranes


CEITEC

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Prof R Vácha No more applications being accepted Funded PhD Project (Students Worldwide)

About the Project

We have shown that a specific class of transmembrane proteins, called scramblases, can facilitate not only spontaneous flip-flop of lipids but also a translocation of other amphiphilic molecules across cellular membranes. However, we miss information about the selectivity of this transport. The goal of the PhD project is to determine specificity of scramblase activity and obtain a molecular understanding of the selectivity. The main tool will be Molecular dynamics simulations with free energy calculations.

 

PLEASE NOTE: before initiating the formal application process to doctoral studies, all interested candidates are required to contact Robert Vácha ([Email Address Removed]) for an informal discussion.

Information about the laboratory at: http://vacha.ceitec.cz/

More information about CEITEC PhD School are available at http://ls-phd.ceitec.cz/.

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