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Self-assembled particulate vaccines for prevention of Q fever

  • Full or part time
  • Application Deadline
    Applications accepted all year round
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Q fever is an infection by the intracellular pathogen Coxiella burnetii that can cause a severe flu-like illness. For some people, Q fever can affect their health and ability to work for many years. The bacteria are spread from animals, mainly cattle, sheep and goats. Current Q fever vaccines are only poorly protective and cause severe adverse effects. Escherichia coli will be bioengineered to assemble selected antigens into discrete particles to serve as self-adjuvanting vaccines which performance will be tested in guinea pigs.

Funding Notes

About the Scholarship

The 2019 Griffith University Postgraduate Research Scholarship has an annual stipend of $27,596 (indexed) for a period of up to three years of full-time study. Please see the GUPRS Conditions of Award for more information: View Website

A successful International applicant will also be awarded a Griffith University International Postgraduate Research Scholarship to cover tuition fees for up to three years. Please see the GUIPRS Conditions of Award for more information: View Website

References

1. Rehm, B. H. A., Bioengineering towards self-assembly of particulate vaccines. Current Opinion in Biotechnology 2017, 48, 42-53.

2. Rehm, B. H. A. et al., Bioengineered polyester beads co-displaying protein and carbohydrate-based antigens induce protective immunity against bacterial infection. Scientific Reports 2018, 8 (1), 1888.

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