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Self funded BMS Project: Assessing the emergence of transient, growth related antibiotic resistance in bacterial populations


   York Biomedical Research Institute


About the Project

Applications accepted for PhD Only

Antimicrobial resistance (AMR) is a significant concern in the battle against bacterial disease. Our understanding of resistance gene occurrence and spread as contributing to AMR is significant. On the other hand, much less is understood about transient resistance that will play very important roles in allowing a subpopulations of a pathogen to persist in the presence of antibiotics and possibly evolve. In this project you will be looking at the role of specific toxin systems in mediating persistence and thus contributing to AMR. Furthermore we are interestd in determining whether some mechanisms that mediate pathogen survival in the host cell, elicit cross protection to antibiotics. The project will focus on Gram negative pathogens, mostly Escherichia coli and Salmonella but can expand into other ESKAPE pathogens as relevant. This project builds upon publications by the supervisors, and will generate new insight into the survival strategies of bacterial pathogens.

The York Biomedical Research Institute at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions. 

Programme: PhD in Biomedical Science (3 years)

Start Date: 1st October 2022

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