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Self funded BMS Project: Harnessing ion channels in immune cells to promote tumour suppression


   York Biomedical Research Institute


About the Project

Applications accepted for PhD Only

A complex network of interactions between different immune cell subsets orchestrates timely and tightly controlled immune responses. Myeloid cells play a critical role in cancer progression by modulating the tumour microenvironment and shaping anti-tumour responses. Infiltration of solid tumours by myeloid cells is a hallmark of cancer and is associated with disease progression and poor clinical outcomes. Distinct subsets of myeloid cells contribute to either pro- or anti-tumour responses, suggesting that their activity can be targeted therapeutically. Increasing evidence suggests that ion channels (particularly those carrying sodium and calcium) play key roles in promoting tumour progression. However, their precise role in the regulation of myeloid cell activity is ill-defined. You will investigate how modulation of sodium and calcium channel signaling in immune cells can harness myeloid cell activity to promote tumour suppression.

The York Biomedical Research Institute at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions. 

Programme: PhD in Biomedical Science (3 years)

Start Date: 1st October 2022

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Funding Notes

This is a self funded research project. Applicants need to have adequate funds to meet the costs of a self-funded research project including tuition fees and living expenses for the duration of the research programme.

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