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Self-funded BMS project: Helminth-induced changes to host haematopoiesis – a permanent problem?


   Department of Biology


York United Kingdom Immunology Parasitology

About the Project

More than a quarter of the global population is infected with a parasitic worm that causes a range of diseases. On-going work in our laboratories is focused on understanding how parasites such as schistosomes cause wide-ranging changes to host bone marrow and re-programme mammalian haematopoiesis. We want to know whether these changes promote parasite persistence and whether they are reversible following parasite clearance. We have found chronic parasite infection changes the bone marrow cytokine microenvironment which in turn alters haematopoietic stem cell differentiation. This project will investigate the cellular and molecular basis of these changes and assess whether this benefits the parasite or the host.

Prospective postgraduate students will have a good first degree in Biomedical Sciences (or a related subject) and a strong interest in the mammalian immune system, haematology, and parasitology. This project will provide extensive training in immunology, haematology, cell biology and molecular techniques (e.g. flow cytometry, imaging, in vivo biology).

The York Biomedical Research Institute at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions. 

Programme: PhD in Biomedical Science (3 years)

Start Date: 1st October 2021 (the student will be affiliated with the Department of Biology)


Funding Notes

This is a self-funded PhD research project. Applicants need to have adequate funds to meet the costs of fees and living expenses for the duration of the PhD programme.

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