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Self funded BMS Project_Investigating the Effects of Glucocorticoids on the Development of Lab Grown Mini-brains.

   York Biomedical Research Institute

About the Project

Glucocorticoids are some of the most commonly prescribed therapeutics worldwide because of their low-cost and anti-inflammatory effects. In treating brain cancer, they provide essential management of the swelling caused by the tumour to prevent damage to the surrounding tissue.

Corticosteroids are also vital to the management of childhood asthma and supporting lung development in preterm infants. However, glucocorticoids interfere with brain development, leading to altered brain structure in response to long-term treatments.

Glucocorticoids activate the glucocorticoid receptor (GR), which is found in all cells. However, despite its ubiquitous nature, different cell types interpret the signal differently. Immune cells respond with the desired anti-inflammatory effects, while the GR response in brain tissue alters tissue development. As with most nuclear receptors, the activated GR functions as a transcription factor (TF) with the co-regulators expressed within the cell defining the response. The project will address the knowledge gap of which co-regulators enable the deleterious GR response in brain tissue, and if they can be targeted to prevent the negative side-effects of glucocorticoid use.

Funding Notes

This is a self funded research project. Applicants need to have adequate funds to meet the costs of a self-funded research project including tuition fees and living expenses for the duration of the research programme.

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