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Self funded BMS Project: Role of the endosomal pathway in regulating sleep and circadian rhythms


   York Biomedical Research Institute

  Dr Sangeeta Chawla,  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

Applications accepted for PhD Only

Ageing and many neurodegenerative disorders are characterized by a progressive loss of neurons in particular brain regions leading to behavioural changes including cognitive decline, sleep disruption and circadian dysregulation. The endosomal pathway is a key regulator of protein degradation and recycling. Dysfunctional endosomes and dysregulation of proteins involved in trafficking and sorting cargo along the endocytic pathway are a hallmark of many neurological conditions including Alzheimer’s and Parkinson’s disease. Circadian rhythms are driven by cellular transcription-translation feedback loops. This project will investigate how endosomal dysfunction affects the molecular mechanisms underlying circadian clocks. It will use molecular, genetic and behavioural approaches in Drosophila to investigate the role of particular endosomal proteins, initially CHMP2B, and associated ESCRT complex machinery in regulating sleep and circadian rhythms.

The York Biomedical Research Institute at the University of York is committed to recruiting extraordinary future scientists regardless of age, ethnicity, gender, gender identity, disability, sexual orientation or career pathway to date. We understand that commitment and excellence can be shown in many ways and have built our recruitment process to reflect this. We welcome applicants from all backgrounds, particularly those underrepresented in science, who have curiosity, creativity and a drive to learn new skills.

Entry Requirements: Students with, or expecting to gain, at least an upper second class honours degree, or equivalent, are invited to apply. The interdisciplinary nature of this programme means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, or students with mathematical backgrounds who are interested in using their skills in addressing biological questions. 

Programme: PhD in Biomedical Science (3 years)

Start Date: 1st October 2022

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Funding Notes

This is a self funded research project. Applicants need to have adequate funds to meet the costs of a self-funded research project including tuition fees and living expenses for the duration of the research programme.

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