It has become increasingly clear that ‘neuro’science research must consider the roles of non-neuronal cells in the central nervous system if integrated brain function is to be ultimately understood. We have by now come to appreciate that astrocytes, the most abundant type of glia cells in the brain, play fundamental roles in neurotransmission, not only by fuelling the underlying cellular processes and by removing waste products, but also by integrating, amplifying, and modulating neuronal signals (Verkhratsky A et al., 2015). Astrocytes handle glucose intake across the blood-brain barrier, contain the glycogen stores of the brain and, following glycolysis, release lactate into the extracellular space. This lactate may support neuronal function in states of increased energy demand, for example during memory formation (Alberini CM et al., 2018). However, beyond energy supply, recent evidence has suggested that lactate also acts as extracellular signalling molecule, for example in context of central arousal to salient stimuli, or in autonomic control (Mosienko V et al., 2015;Tang F et al., 2014;Teschemacher AG et al., 2015;Vaccari-Cardoso B et al., 2022).
Whilst lacking electrical excitability, astrocytes express a plethora of G-protein-coupled receptors and highly complex intracellular signalling cascades of which we currently have only limited understanding. Over the recent decade, molecular and imaging tools suitable for investigating the impact of these on metabolic signalling have been developed (Vaccari Cardoso B et al., 2021). This research project will use astrocytes in dissociated and slice cultures, viral vector transgenesis, confocal imaging and biosensor electrode measurements to study the effects of GPCR activation on lactate production and release.
How to apply:
MSc by Research (MScR) is a 1-year research degree that provides an intensive lab-based training and a preparation for PhD study. You will carry out your studies as part of your research group – like a PhD student does. Towards the end of the year, you write up a thesis on your research and are examined on this. This degree suits students wanting to gain maximum research experience in preparation for PhD applications.
We are keen to recruit a diverse range of students and to ensure our research is open to all. We particularly welcome applications from groups traditionally under-represented in life sciences research. Please check the University webpages for the current tuition fee information. Most MScR projects also require a bench fee. This varies depending on the research and your project supervisor can tell you the bench fee for the project.
Please follow the link below and apply to the Faculty of Life Sciences, School of Physiology, Pharmacology and Neuroscience, selecting the programme "Physiology, Pharmacology and Neuroscience (MSc by Research)".
PhD Physiology, Pharmacology and Neuroscience | Study at Bristol | University of Bristol