About the Project
Brain function relies upon specific patterns of wiring between individual neurons. Neurons connect via their axons to other cells in their vicinity (locally) and also to other brain regions (long-range). Both types of connection can be exquisitely precise, but we have much to learn about the logic of neuronal connectivity from one region to another. This issue is particularly pressing in the cerebellum (or ‘little brain’) which is composed of three discrete structures (cortex, nuclei and inferior olive) that are linked via long-range projections. The aim of this project is to map projection patterns of single cells from the cerebellar cortex to the nuclei using molecular tools (e.g. genetically encoded fluorescent proteins) [1,2] to determine the rules governing connectivity between these two regions .
You will join a dynamic and multidisciplinary team who apply a range of approaches (2-photon imaging, high density electrophysiological recording, patch clamp, computational modelling) to understand mechanisms of motor control and learning in the intact brain. During this project, there will be opportunities to collaborate with group members to gain experience of other in vivo techniques and to present your work at international conferences.
For more information, please contact Paul Chadderton (firstname.lastname@example.org).
Please apply to the Faculty of Life Sciences, School of Physiology and Pharmacology, selecting the programme 'MSc by Research'
1. Cai et al. (2013) Nat Methods 10: 540-7.
2. Song et al. (2018) Cell Rep 24: 1071-80.
3. Herzfeld et al. (2015) Nature 526: 439-4
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