About the Project
Major depressive disorder is one of the most challenging conditions facing modern society and is associated with significant personal and societal costs. Until recently, treatments for depression were limited and many patients either failed to respond or found side effects to much to tolerate. These treatments also had a delayed onset of action meaning patients did not show improvement for many weeks after initial diagnosis and treatment. This all changed with the discovery that the NMDA antagonists and drug of abuse, ketamine, can reduce symptoms of depression as soon as 1 hr after treatment and a single dose can have effects which last up to 14 days. However, ketamine is not an ideal treatment due to side effects, abuse liability and risks of adverse effects such as bladder and kidney problems (Robinson, 2018). This project will investigate the underlying molecular mechanisms which contribute to ketamine's effects and use this knowledge to test potential alternative treatments which achieve similar efficacy but with reduce risks. The student will have an opportunity to gain hands on in vivo skills in behavioural neuroscience and psychopharmacology.
Please apply to the Faculty of Life Sciences, School of Physiology and Pharmacology, selecting the programme 'MSc by Research'
Based on your current searches we recommend the following search filters.
Based on your current search criteria we thought you might be interested in these.