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SELF-FUNDING MSc BY RESEARCH PROJECT: Probing the projections of different types of dopamine neurons


   School of Physiology, Pharmacology & Neuroscience

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  Dr Paul Dodson  Applications accepted all year round  Self-Funded PhD Students Only

About the Project

 What makes one neuron different from another? How can we define different “types” of cells? Are cell types important?

In Parkinson’s disease some dopamine neurons seem to be more vulnerable to neurodegeneration. Furthermore, there is emerging evidence that different types of dopamine neuron may play different roles in encoding features such as reward and movement, suggesting that investigating cell-types might be key to advancing our understanding of these neurons.

The aim of this project is therefore to define different sub-populations of dopamine neuron. To achieve this, we will use retrograde tracing to identify groups of neurons projecting to different regions and then employ immunohistochemistry to identify combinations of protein-markers expressed by each sub-population.

The project will involve using viral (or other) tracers, immunohistochemistry, microscopy, and image analyses to quantify cells expressing different proteins. 

For informal queries on the project please email Dr Paul Dodson – [Email Address Removed]


Funding Notes

This project is for students who can fund the project themselves; there is no financial support.
Please apply to the Faculty of Life Sciences, School of Physiology and Pharmacology, selecting the programme 'MSc by Research'
https://www.bristol.ac.uk/study/postgraduate/2022/life-sciences/phd-physiology-pharmacology/

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