What makes one neuron different from another? How can we define different “types” of cells? Are cell types important?
In Parkinson’s disease some dopamine neurons seem to be more vulnerable to neurodegeneration. Furthermore, there is emerging evidence that different types of dopamine neuron may play different roles in encoding features such as reward and movement, suggesting that investigating cell-types might be key to advancing our understanding of these neurons.
The aim of this project is therefore to define different sub-populations of dopamine neuron. To achieve this, we will use retrograde tracing to identify groups of neurons projecting to different regions and then employ immunohistochemistry to identify combinations of protein-markers expressed by each sub-population.
The project will involve using viral (or other) tracers, immunohistochemistry, microscopy, and image analyses to quantify cells expressing different proteins.
How to apply:
MSc by Research (MScR) is a 1-year research degree that provides an intensive lab-based training and a preparation for PhD study. You will carry out your studies as part of your research group – like a PhD student does. Towards the end of the year, you write up a thesis on your research and are examined on this. This degree suits students wanting to gain maximum research experience in preparation for PhD applications.
We are keen to recruit a diverse range of students and to ensure our research is open to all. We particularly welcome applications from groups traditionally under-represented in life sciences research. Please check the University webpages for the current tuition fee information. Most MScR projects also require a bench fee. This varies depending on the research and your project supervisor can tell you the bench fee for the project.
Please follow the link below and apply to the Faculty of Life Sciences, School of Physiology, Pharmacology and Neuroscience, selecting the programme "Physiology, Pharmacology and Neuroscience (MSc by Research)".
PhD Physiology, Pharmacology and Neuroscience | Study at Bristol | University of Bristol