Coventry University Featured PhD Programmes
Imperial College London Featured PhD Programmes
University of Hull Featured PhD Programmes

SELF-FUNDING MSc BY RESEARCH PROJECT: Using Zebrafish to Study Heart Disease and Tissue Regeneration

School of Physiology and Pharmacology

Bristol United Kingdom Cardiology

About the Project

Our Main Interests and Skills:

·      In vivo animal models

·      Live imaging and sophisticated microscopy

·      Inflammation

·      Tissue repair and regeneration (skin and heart)

·      Heart disease models (heart attack, heart failure, arrhythmias)

·      Cell-cell communication

·      CRISPR technology

 Our lab is interested in modelling different aspects of heart disease and tissue repair/regeneration using zebrafish as a model. We are particularly interested in the inflammatory response to tissue injury and the roles this may play in promoting regeneration of damaged organs. The inflammatory response to an acute or ischaemic injury (such as a heart attack) is an inevitable and necessary part of the repair process but directly drives subsequent fibrosis and scar formation in mammals. Adult zebrafish, by contrast, deposit scar tissue following tissue injury but later resolve it entirely allowing for complete regeneration of organs such as the skin and heart. Our studies show that subtle changes in different immune cells are required for scar removal and tissue regeneration in zebrafish, but we still don’t fully understand how this is controlled. We have several projects currently available in the lab including: investigating how ageing effects immune cells and tissue repair and regeneration; live imaging the movement of immune cells into the heart; determining which genes are involved in controlling immune cell behaviour during regeneration; using CRISPR technology to introduce specific cardiovascular disease-causing mutations; deciphering the ways cells communicate during repair and regeneration.

If you are interested in doing any of these projects for a MSc by Research or would like to hear more or visit the lab, please get in touch,

Funding Notes

This project is for students who can fund the project themselves; there is no financial support.
Please apply to the Faculty of Life Sciences, School of Physiology and Pharmacology, selecting the programme 'MSc by Research'
View Website

Email Now

Insert previous message below for editing? 
You haven’t included a message. Providing a specific message means universities will take your enquiry more seriously and helps them provide the information you need.
Why not add a message here

The information you submit to University of Bristol will only be used by them or their data partners to deal with your enquiry, according to their privacy notice. For more information on how we use and store your data, please read our privacy statement.

* required field

Your enquiry has been emailed successfully

FindAPhD. Copyright 2005-2021
All rights reserved.