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Self-Navigating Nanocarriers for Intracellular Protein Delivery

   School of Pharmacy

   Applications accepted all year round  Competition Funded PhD Project (UK Students Only)

About the Project

Protein-based therapeutics have shown remarkable success in modulating extracellular targets; however, effective intracellular delivery remains a key challenge in biotherapeutics. Current intracellular protein delivery strategies rely on endocytic mechanisms, resulting in endosomal entrapment and protein degradation. The current project will engineer novel self-navigating nanocapsules, enabling effective cytoplasmic protein delivery and sub-organelles targeting following endocytosis-independent cellular uptake. This elegant and straightforward protein delivery approach to intracellular targets could open the door to novel treatment opportunities in many relevant disorders, including cancer, metabolic and neurodegenerative diseases.

Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, Chemistry, Engineering, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date.

This project will provide a unique opportunity for excellent students to work in a stimulating multidisciplinary team. The candidate will be designing and characterising novel nanocarriers for efficient intracellular protein delivery. The successful candidate will be a highly motivated, hard-working graduate with excellent communication and organisational skills.

The project will offer innovative approaches for biologics delivery. The PhD student will be encouraged to engage in a variety of impact activities, disseminate the research project findings through publications in relevant peer-reviewed journals, present the results of the study at conferences (in-person and/or online), and make them accessible to general public through broader channels, such as social media and popular science outlets.  

Applicants should apply through the University's Direct Application Portal:

Funding Notes

Department for the Economy studentships are available for eligible UK and Irish residents. This is a three year studentship beginning on 2nd October 2023, the deadline for applications is the 30th January 2023. The successful candidate will receive a stipend and have their tuition fees paid for. For more details, please see the following link: View Website

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