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Sensing and memorising abiotic stress through the DNA integrity pathway in plants

  • Full or part time
  • Application Deadline
    Tuesday, January 15, 2019
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

How plants cope with environmental stresses is a fundamental question for sustainable agriculture. We recently discovered that in parallel to the canonical DNA damage signalling pathway, the RETINOBLASTOMA RELATED (RBR) together with the E2F transcription factors play important transcriptional and non-transcriptional roles to signal DNA damage on the plant chromatin. Evidence is accumulating that this signaling mechanism is also used to sense biotic and abiotic stresses. The model is that these stress signals evoke disruption and arrest in DNA synthesis that recruits RBR to the stalling DNA replication sites together with chromatin modifiers, which could be involved both in evoking adaptation responses as well as in stress memory. Within this project we will investigate how and where on chromosomes the RBR complexes become recruited upon environmental stresses and how the chromatin landscape is modified to facilitate environmental adaptation.

Please visit our BBSRC DTP webpage to obtain more information on how to apply. Applications are due no later than Tuesday, 15 January 2019. Shortlisted candidates will be notified in early February to schedule an in-person interview during the weeks of 11-22 February, 2019. Any questions about the application process should be sent to . To contact the supervisors see ‘email now’ link below

References

1. Bögre L., Ökrész L., Henriques R., and Anthony R.G. (2003) Growth signalling pathways in Arabidopsis, the protein kinase AGC Trends in Plant Science Trends Plant Sci, 8, 424-431.
2. Anthony, R. G., Henriques, R., Helfer, A., Mészáros, T., Gabino R., Testerink, C., Munnik, T., Deák, M., Koncz C., and Bögre L. (2004). A protein kinase target of a PDK1 signalling pathway is involved in root hair growth in Arabidopsis. EMBO J. 23, 572-581.
3. Weingartner, M. Criqui, M.-C., Meszaros T., Derevier, A., Schmit A.-C. Erhardt, M. Helfer, A. Binarova P., Bögre L. and Genschik P. (2004). Expression of a non-degradable cyclin B1 affects plant development, cell shape and leads to endomitosis through abnormal cytokinetic microtubule organisation. Plant Cell 16, 643-657.
4. Leeuwen, W., Okresz, L., Bogre, L., and Munnik, T. (2004). Learning the lipid language of plant signalling. Trends in Plant Science 9:378-84
5. Magyar Z, De Veylder L, Atanassova A, Bako L, Inze D, Bogre L. (2005) The Role of the Arabidopsis E2FB Transcription Factor in Regulating Auxin-Dependent Cell Division. Plant Cell. 17(9):2527-41

How good is research at Royal Holloway, University of London in Biological Sciences?

FTE Category A staff submitted: 24.00

Research output data provided by the Research Excellence Framework (REF)

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