About the Project
Remarkably post translational alterations perform both the role of a signalling molecule and also a structural component, and there is an emerging consensus that these act to accurately regulate proper DNA repair.
In our recent preliminary work we have identified several new modifications and shown that they are critical to proper DNA replication and repair. We now intend to map the cellular context of these changes and, critically to map out their impact on therapeutic strategies and DNA repair mechanisms.
A PhD project in this area is offered to an able, enthusiastic student. The project will entail training in molecular biology techniques, including cloning and cell biology including immunofluorescence, DNA fibre approaches and specialist DNA repair assays. Mentoring and training in scientific design, writing and presentations will also be given and the student will be part of a vibrant research laboratory, and more widely an integrated and fast-moving Institute with an interest in cancer research. A student with biochemistry and cell biology experience is preferred.
Densham, R. M., A. J. Garvin, H. R. Stone, J. Strachan, R. A. Baldock, M. Daza-Martin, A. Fletcher, S. Blair-Reid, J. Beesley, B. Johal, L. H. Pearl, R. Neely, N. H. Keep, F. Z. Watts and J. R. Morris (2016). "Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection." Nat Struct Mol Biol 23(7): 647-655.
Morris, J. R., C. Boutell, M. Keppler, R. Densham, D. Weekes, A. Alamshah, L. Butler, Y. Galanty, L. Pangon, T. Kiuchi, T. Ng and E. Solomon (2009). "The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress." Nature 462(7275): 886-890.
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