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Simultaneous use of genetic and non-genetic information in the evaluation of screening and diagnostic testing pathways: Development of multiparameter evidence synthesis methodology (T3/9)

  • Full or part time
  • Application Deadline
    Thursday, December 05, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Genetic based information is increasingly being used in screening and diagnostic contexts often used alongside more traditional types of diagnostic medical tests.

The overarching aim of this project is to develop a robust methodology for the simultaneous synthesis of genetic and non-genetic screening/diagnostic information, utilising the totality of evidence available, for the clinical and cost-effective evaluation of realistic clinical testing and diagnosis pathways to inform more targeted treatment leading to better health outcomes for patients. . This project will utilise a multi-parameter evidence synthesis approach, which has proved very successful in other synthesis contexts (including network meta-analysis).

The framework will be developed using several case studies including screening for familial hypercholesterolemia where it will be possible to assess the impact of the synthesis methodology on decision making using the economic decision model developed by researchers at the University of York.

In doing the above, it is hoped that valuable insights can be gained into the limitations and relative usefulness of the various forms of evidence, and this will allow guidance to be developed on the design of future primary studies in screening and diagnosis to maximise its usefulness to decision making.

Entry Requirements

UK Bachelor Degree with at least 2:1 in a relevant subject or overseas equivalent.

University of Leicester English language requirements apply.

This project is available for UK/EU/International students.

How to Apply

Application advice and application link:

https://le.ac.uk/study/research-degrees/funded-opportunities/wellcome-trust-2020

Funding Notes

This project is funded by the Wellcome Trust Doctoral Training Programme.

Stipend for the PhD: Year 1 £19,919; Year 2 £21,542; Year 3 £23,298; Year 4 £23,997 (rates as of September 2019).

4 year PhD fee waiver at UK/EU rates.

International applicants need to ensure they can fund the difference between UK/EU and international fees for the duration of their studies.

We also will offer 2 fully funded places to international applicants from Lower-middle income countries per year. These will provide a full overseas fee waiver and stipend for 4 years.

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