Prof Chris Jones, Prof J Shipley
No more applications being accepted
Funded PhD Project (Students Worldwide)
About the Project
Gliomatosis cerebri (GC) is a rare brain tumour that mostly affects children and young adults. Unlike other brain tumours, little is known about this type of cancer, and survival is very poor, with most patients succumbing to their disease within 18 months of diagnosis. GC is a radiological diagnosis rather than a pathological one, as there appear to be few histological or molecular differences between GC biopsy samples and those from established diffuse glioma subgroups.
We hypothesise that the unique infiltrative phenotype of GC may be driven by extensive intratumoral heterogeneity and/or specific tumour microenvironmental interactions that have hitherto gone unrecognised.
We aim to take advantage of cutting-edge single cell-based techniques to deconvolute the tumour- and non-tumour cell architecture of GC, and to identify strategies to modulate these key cellular processes to guide new therapies for children and young adults with this disease.
The proposed PhD studentship will be registered with Prof Chris Jones at the ICR in London, however will form part of a joint project with Dr Mariella Filbin (Dana-Farber Cancer Institute, Boston) and Dr Mara Vinci (Bambino Gesu Hospital, Rome) to take advantage of worldwide expertise in a wide range of techniques which have not been studied in the context of GC previously.
Keywords:
Molecular pathology
Molecular and cellular biology
Single cell biology
Bioinformatics
To apply please see the ICR website for full eligibility criteria and instructions on how to apply
https://www.icr.ac.uk/studying-and-training/phds-for-science-graduates/phd-studentship-projects
Funding Notes
Students receive an annual stipend, currently £21,000 per annum, as well as having tuition fees (both UK/EU and overseas) and project costs paid for the four-year duration. We are open to applications from any eligible candidates and are committed to attracting and developing the best minds in the world. Eligibility criteria can be found on the link above.
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