Cytotoxic therapy has been the standard of care over the last 30 years for Blood malignancies. But majority of the time, it fails to cure the patient (5 years survival rate lower than 30%). Therefore, there is an urgent need for the development of more specific and efficient therapies. Single cell RNA sequencing have been used to investigate the heterogeneity during the development, maintenance and responses to treatment of diseases such as cancers. The main aims of this project are to use scRNA-seq to define the cellular hierarchy in blood malignancies and to determine how different cell types are affected by drug/compound treatments and to identify genes critical for the maintenance of the most immature cell populations.
Candidates are expected to hold (or be about to obtain) a minimum upper second class honours degree in biology or computer science. Candidates with experience in haematopoiesis or with an interest in single cell omics technologies are encouraged to apply.
How to Apply
For information on how to apply for this project, please visit the Faculty of Biology, Medicine and Health Doctoral Academy website (https://www.bmh.manchester.ac.uk/study/research/apply/). Informal enquiries may be made directly to the primary supervisor. On the online application form select the PhD Bioinformatics.
For international students, we also offer a unique 4 year PhD programme that gives you the opportunity to undertake an accredited Teaching Certificate whilst carrying out an independent research project across a range of biological, medical and health sciences. For more information please visit www.internationalphd.manchester.ac.uk
Equality, Diversity & Inclusion
Equality, diversity and inclusion is fundamental to the success of The University of Manchester, and is at the heart of all of our activities. The full Equality, diversity and inclusion statement can be found on the website