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Single molecule analysis of myotonic dystrophy mutant transcripts

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  • Full or part time
    Prof J D Brook
  • Application Deadline
    No more applications being accepted
  • Competition Funded PhD Project (European/UK Students Only)
    Competition Funded PhD Project (European/UK Students Only)

Project Description

Myotonic Dystrophy is the most common form of muscular dystrophy in adults. It is caused by transcribed repeat expansion sequences that remain in the nuclei of patients’ cells where they form distinct foci or spots, which interfere with key molecular processes. We are developing therapeutic compounds for this condition which eliminate the foci in patients’ cells. This project aims to understand the underlying molecular mechanisms that lead to foci formation and disruption, using state-of the-art microscopy and image analysis, alongside novel RNA sequencing techniques. Using a combination of molecular cell biological approaches, it should be possible to determine the molecular mechanism underlying foci formation and therefore improve attempts to develop a treatment for this condition.

Funding Notes

The studentships will commence in October 2020, and a stipend (£15,009 for 2019/20) and fee waiver for 3.5 years is available for UK applicants, plus research training support grant, travel and laptop allowance.

Fully funded studentships are available for UK applicants. EU applicants able to confirm that they have been resident in the UK for at least three years before October 2020 may also be eligible for a full award. EU students who are not able to prove that they meet the residency criteria may apply for a fees only award. Interviews take place week commencing 17 February 2020.


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