Single molecule science: new experimental approaches to measuring the charge, size and 3D conformation of single biomolecules in solution


   Department of Chemistry

   Applications accepted all year round  Funded PhD Project (UK Students Only)

About the Project

Prof. Madhavi Krishnan's group is looking for bright, highly motivated and committed students for PhD research in the broad area of single molecule biophysics and nanoscience. Our lab has recently developed the ability to trap molecular-scale entities in solution, e.g., biological macromolecules such as proteins and DNA, without the use of external forces (Nature, 2010; Nature Nanotechnology, 2012; Nature Nanotechnology, 2017). Our "field-free" trap now enables us to study and measure the physical properties of macromolecules such as their electrical charge, size and conformation with unprecedented precision, in real time.

Our new experimental technique (escape time electrometry) has wide-ranging implications as a next generation chip-based bioanalytical technology and we are currently looking for bright, highly motivated PhD students with a strong background in physics, engineering, biophysics, or physical chemistry, and a keen interest in experimental work to join us in a range of exciting new problems in this emerging area of single molecule measurement. Our experimental approach mainly involves optical imaging, nanofluidics and nanofabrication. We are interested in candidates with a keen interest in physics/physical chemistry/engineering based experimental work in any or several of the following areas: nanoscience, optics and microscopy, nanofabrication, single molecule measurements, biophysics and biochemistry. Interest in theoretical modelling is also highly welcome, as PhD projects in our group tend to have a significant contribution of experiment, data analysis and computational work.

The group offers a close-knit vibrant environment for highly motivated individuals in cutting edge scientific discovery and technological innovation areas. Interested applicants should send a cover letter (explaining your background and motivation), CV including contact information for your references, and publication record (if applicable) as a single PDF file by email to

Chemistry (6) Materials Science (24) Physics (29)

Register your interest for this project


Search Suggestions
Search suggestions

Based on your current searches we recommend the following search filters.