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Skin protective mechanisms of bioactives from citrus waste


Project Description

The skin is the largest organ in our body and a barrier to the external environment. It is subjected to daily stress from biotic and abiotic factors which might affect the skin in its functionality and increase the risk to develop skin related disorders such as inflammatory skin conditions, psoriasis and eczema.
This project will investigate the mechanisms by which phytochemicals influence SBF, through targeted interactions with cellular inflammatory and autophagy pathways, and the skin microbiome. Flavonoids derived from citrus peels have been identified as a highly potent small molecule group, however, their role in the context of skin is not fully clarified.
The proposed project will involve in vitro cell culture studies to elucidate the structure-function relationship of different flavonoid compounds and their effectivity on signaling pathways (inflammation and oxidative stress) in keratinocytes and fibroblasts.
The aim is also to perform a proof of concept study in humans to validate the cell culture findings on skin protection and barrier function, and to investigate whether citrus flavonoids modulate the skin microbiome.

Funding Notes

White Rose BBSRC Doctoral Training Partnership in Mechanistic Biology
4 year fully-funded programme of integrated research and skills training, starting Oct 2020:
• Research Council Stipend
• UK/EU Tuition Fees
• Conference and research funding

Requirements:
At least a 2:1 honours degree or equivalent. We welcome students with backgrounds in biological, chemical or physical sciences, or mathematical backgrounds with an interest in biological questions.

EU candidates require 3 years of UK residency to receive full studentship

Not all projects will be funded; the DTP will appoint a limited number of candidates via a competitive process.

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Related Subjects

How good is research at University of Leeds in Biological Sciences?

FTE Category A staff submitted: 60.90

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