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Slow molecular dynamics in solid protein samples studied by solid-state NMR techniques


   Faculty of Natural Sciences II: Chemistry, Physics and Mathematics

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  Dr Alexey Krushelnitsky  No more applications being accepted  Funded PhD Project (Students Worldwide)

About the Project

One PhD student position is available in the NMR group of Institute of Physics, Halle University, Germany. The successful candidate will take part in the project aiming at the study of molecular dynamics in solid protein samples (protein crystals, amorphous powders, sediments) by means of solid-state NMR techniques. Special emphasis is placed on low-frequency (micro- to millisecond time scale) motions. The amplitudes and time scales of the slow protein motions in such samples are controlled by inter-protein interactions and hence, these can be informative reporters on the density packing, strength of the non-covalent contacts between different proteins, properties of hydration layers between proteins, etc. The NMR experiments used in this project include T1rho-relaxometry, exchange (stimulated echo) and recoupling methods. This project combines extensive experimental work with thorough theoretical and numerical analysis of the NMR data. The minimum duration of the contract is two years with possible extension. The necessary prerequisites for the application are good knowledge of NMR basics, practical experience in conducting NMR experiments and programming skills. For more details and applications please contact Dr. Alexey Krushelnitsky, [Email Address Removed].


Funding Notes

The project is funded by Deutsche Forschungsgemeinschaft (DFG)
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