Small-molecule inhibitors of adenylate cyclases

Dr Z Janeba
Thursday, February 21, 2019
Competition Funded PhD Project (Students Worldwide)

Organic Chemistry, Institute of Organic Chemistry and Biochemistry Prague

About This PhD Project

Project Description
Funding Notes
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References

Project Description

Inhibitors (modulators in general) of bacterial (e.g. from Bordetella pertussis and Bacillus anthracis) and/or human adenylate cyclases (ACs) have a great therapeutic potential in treatment of either infectious diseases or diseases as cancer, chronic pain, neurodegenerative disorders and asthma. The aim of the thesis will be design, synthesis and biological evaluation (SAR study) of novel inhibitors of ACs. The key group of compounds are structurally modified nucleosides and nucleotides.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:
https://www.uochb.cz/web/structure/797.html

You can apply online via our application form http://www.uochb.cz/phdapplication/index.php/PhDrecruitment

Enquiries

All general enquiries should be directed to Katerina Solcova ([email protected]). Scientific enquiries can be addressed to the supervisor ([email protected]).

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

1. Šmídková, M. et al.: Amidate prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine as inhibitors of adenylate cyclase toxin from Bordetella pertussis. Antimicrobial Agents and Chemotherapy 58: 664–671, 2014.
2. Břehová P. et al.: Design and synthesis of fluorescent acyclic nucleoside phosphonates as potent inhibitors of bacterial adenylate cyclases. ChemMedChem 11: 2534–2546, 2016.
3. Česnek M. et al.: Nucleobase modified adefovir (PMEA) analogues as potent and selective inhibitors of adenylate cyclases from Bordetella pertussis and Bacillus anthracis. ChemMedChem 13: 1779–1796, 2018.

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