An important limitation in the treatment of cancer with therapeutics is the inability to achieve therapeutically effective local drug concentrations avoiding healthy tissue damage. Liposomes are phospholipid-based delivery systems, clinically used for the transport of therapeutics. The clinical use of phospholipid-based delivery systems is based on reduced toxicity to healthy tissues with a simultaneous increase in tumour accumulation. However, the accumulation of drug-loaded liposomes in the tumour tissue does not necessarily lead to a higher drug bioavailability.
This project focuses on designing smart (stimuli-responsive) nanosystems for on-demand drug release for anti-cancer drug delivery. The scientific approach of this project is to fabricate new types of responsive drug delivery systems (e.g. temperature, redox or hypoxia). The developed smart nanoparticles will be characterised, and their biological activity in vitro and in vivo will be evaluated. This highly interdisciplinary project combines expertise in formulation and biological testing and will provide a unique opportunity for excellent students to work in a stimulating interdisciplinary team.
Applicants should have a 1st or 2.1 honours degree (or equivalent) in a relevant subject. Relevant subjects include Pharmacy, Pharmaceutical Sciences, Biochemistry, Biological/Biomedical Sciences, Chemistry, Engineering, or a closely related discipline. Students who have a 2.2 honours degree and a Master’s degree may also be considered, but the School reserves the right to shortlist for interview only those applicants who have demonstrated high academic attainment to date.