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  Spatio-temporal modelling of pathogens in wastewater concentration to inform public health policies


   MRC-PHE Centre for Environment and Health

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  Prof Marta Blangiardo  No more applications being accepted  Funded PhD Project (UK Students Only)

About the Project

We invite applications for two 3-year PhD studentship in Environmental statistics within the Environment and Health Statistics group, part of the MRC Centre for Environment and Health.

We develop and apply statistical methods driven by problems in environmental exposure and environmental epidemiology. Our applications span from climate change and its impact on health, to spatio-temporal surveillance and nowcasting of disease incidence and prevalence, to the evaluation of the impact of policies on population health. To answer these public health questions we develop and employ a wide range of methods, mainly in the Bayesian statistical framework, exploiting the data structure in space and time. We closely collaborate with other department across Imperial, as well as with public health institutions within the UK and internationally.

We are now seeking outstanding candidates for one of two available PhD projects:

1.      “Spatio-temporal modelling of pathogens in wastewater concentration to inform public health policies” (Supervisors: Marta Blangiardo, Matt Wade – UKHSA): Wastewater-based epidemiology (WBE) is defined as a collection of tools and methods for surveillance and monitoring disease outbreaks using biochemical analysis of wastewater samples as the primary outcome measure. The first use of WBE was to track illicit drug use. Over the years, WBE has been successfully used in polio eradication and for retrospective prediction of several disease outbreaks, such as noroviruses and hepatitis A, especially in resource-limited settings. During the COVID-19 pandemic, WBE has been recognised as an economically efficient approach for disease surveillance and methods to detect the presence of SARS-CoV-2 RNA in wastewater have been developed in a number of countries. The student will develop a spatio-temporal statistical model to estimate the relationship between pathogen concentration in wastewater at selected point locations (wastewater programme network) and a set of covariates which represent socio-demographic and environmental characteristics of the network catchment areas. Based on this they will provide probabilistic prediction of spatio-temporal pathogen concentration in wastewater at fine resolution across the study region and evaluate the extent to which wastewater can be used to track “traditional” metrics of the disease measured using clinical data and/or survey data and to investigate the form of the relationship between the wastewater metric and the traditional metrics (e.g. in terms of lag and population characteristics). Finally, they will build a dynamic tool which can provide early warning to inform public health interventions.

ELIGIBILITY

Candidates should hold, or achieve by the start of the programme, a Master's degree in addition to a Bachelor's degree with a UK First- or Upper Second-Class honours grade or equivalent in a relevant life science or quantitative science subject. Candidates must have strong statistical/computational skills.

Candidates MUST start the PhD by 1st October 2023 at the latest.

Applications from unsuccessful candidates in previous recruitment rounds for MRC-CEH studentships will not be considered.

Studentships include funding for Home tuition fees and a stipend of £19,668 per annum.

This studentship is only available to candidates who are eligible for home tuition fee status.

APPLICATION

The application form can be here. It should be completed electronically and e-mailed to [Email Address Removed].

For any queries contact [Email Address Removed] or [Email Address Removed].

Applicants with relevant knowledge, skills and ambition outside the scope of the projects listed are encouraged to apply (relevant projects will be identified following successful interview).

Incomplete applications will not be considered.

The closing date for applications is 1 April 2023. 

The MRC Centre and the NIHR HPRUs are committed to equality of opportunity, to eliminating discrimination and to creating an inclusive working environment.


Environmental Sciences (13) Mathematics (25) Medicine (26) Nursing & Health (27) Politics & Government (30)

 About the Project