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Spectroscopic Studies of Protein Fibrils

  • Full or part time
  • Application Deadline
    Thursday, February 21, 2019
  • Competition Funded PhD Project (Students Worldwide)
    Competition Funded PhD Project (Students Worldwide)

Project Description

Many biological processes involve aggregation of proteins into insoluble aggregates, "fibrils". Their properties are studied, for example, to find ways how to prevent neurodegenerative diseases. In our laboratory we use optical spectroscopic, computational and other methods to understand basic principles of fibril formation and structure. Particular aim of the thesis is to develop measurement and interpretation procedures for the modern spectroscopy of Raman optical activity, the topic involves spectroscopic experiments as well as computational modeling.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:
https://www.uochb.cz/web/structure/797.html

You can apply online via our application form http://www.uochb.cz/phdapplication/index.php/PhDrecruitment

Enquiries

All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

1. Průša, J.; Bouř, P. Chirality 2018, 30, 55-64. “Transition dipole coupling modeling of optical activity enhancements in macromolecular protein systems.“
2. Kessler, J.; Yamamoto, S.; Bouř, P. Phys. Chem. Chem. Phys. 2017, 19, 13614-13621. “Establishing the link between fibril formation and Raman optical activity spectra of insulin.”

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