Insoluble proteins aggregates, "fibrils", posses interesting properties and occur in many biological processes. Understanding their behavior may help to limit some neurodegenerative diseases (Parkinson, Alzheimer, mad cow...). We will use optical spectroscopic and computational methods to understand fibril behavior and structure, and potentially suggest ways to regulate their formation. We will focus on measurement and interpretation procedures for the modern spectroscopy of vibrational optical activity, which in the past provided unique information about the structure of similar biomolecules.
How to apply
To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.
For more information visit our website “Call for PhD applications 2020”: https://www.uochb.cz/en/phd-program
If you decided to apply, please do so online via our application form: https://www.uochb.cz/en/call-for-phd-applications
Průša, J.; Bouř, P. Chirality 2018, 30, 55-64. “Transition dipole coupling modeling of optical activity enhancements in macromolecular protein systems.“
Kessler, J.; Yamamoto, S.; Bouř, P. Phys. Chem. Chem. Phys. 2017, 19, 13614-13621. “Establishing the link between fibril formation and Raman optical activity spectra of insulin.”