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Spectroscopic studies of sugar-lectin interactions


Project Description

Lectins are carbohydrate-binding proteins that control various functions in living organisms including the cell-cell interaction, inflammatory and immune response, fertilization, adhesion and virulence of pathogens. Particularly galectins (defined by their binding specificity for galactosides) are in the center of many research studies as immune checkpoints in pathogenesis, or tumor progression and metastasis. Ability to design new galectin inhibitors that would suppress these negative processes envisages not only understanding the carbohydrate-lectin structure, but also requires knowing the conformational behavior of the inhibitor in unbound state. In the thesis, we propose to prepare carbohydrate conjugates bearing metal tags that allow to measure paramagnetic NMR pseudo-contact shifts (PCS) and circularly polarized luminescence (CPL) sensitive to the conformation and to close environment. The interpretation of experiment is not straightforward and theoretically based predictions will be developed, to understand the spectral parameters.

How to apply

To apply for a PhD study at IOCB Prague, you must hold a Master’s degree (MSc) or the equivalent of the MSc in similar field (four or five year undergraduate degree). The application can be submitted before obtaining the Master’s degree, however, the applicant should obtain the degree within five months after the application deadline.

For more information visit our website “Call for PhD applications 2019”:
https://www.uochb.cz/web/structure/797.html

You can apply online via our application form http://www.uochb.cz/phdapplication/index.php/PhDrecruitment

Enquiries

All general enquiries should be directed to Katerina Solcova (). Scientific enquiries can be addressed to the supervisor ().

Funding Notes

Regular monthly income of students at IOCB Prague varies depending on the faculty scholarship and supervisor's financial options.

References

1. Wu, T.; Kessler, J.; Kaminský, J.; Bouř P. Chem. Asian J. 2018, doi.: 10.1002/asia.201801157 “Recognition of Oligosaccharides by Chirality Induced in Europium (III) Compounds.”
2. Canales, A. et al., Angew. Chem. Int. Ed. 2017, 56, 14987. “Breaking the Limits in Analyzing Carbohydrate Recognition by NMR Spectroscopy: Resolving Branch-Selective Interaction of a Tetra-Antennary N-Glycan with Lectins

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