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Splicing control in tumour angiogenesis. Self funded Medical Studies PhD

  • Full or part time
  • Application Deadline
    Monday, September 16, 2019
  • Self-Funded PhD Students Only
    Self-Funded PhD Students Only

Project Description

Lead supervisor: Dr Seb Oltean, College of Medicine and Health, University of Exeter.

Project description:

Abnormal angiogenesis is one of the hallmarks of cancer; tumours need to grow new vessels to be able to survive and spread in the organism. There is therefore an important need to understand the mechanisms of regulation of angiogenesis and try to manipulate it for therapeutic advantage. While several levels of regulation have been quite well studied – eg transcription factors, signalling molecules, miRNAs - it has become clear in the last few years that alternative splicing also plays a major role in this regulation

Alternative splicing of pre-mRNA allows the generation of multiple splice isoforms from a given gene, which can have distinct functions. In fact, splice isoforms can have opposing functions and there are many instances whereby a splice isoform acts as an inhibitor of the canonical isoform function, thereby adding an additional layer of regulation to important processes.
Our lab has studied extensively the regulation of pro- and anti-angiogenic VEGF-A splice isoforms. However, there are many key molecules involved in angiogenesis that have splice isoforms e.g. VEGFR1, VEGFR2, NRP-1, FGFRs, Vasohibin-1, Vasohibin-2, HIF-1α, Angiopoietin-1 and Angiopoietin-2.
This project will explore how these isoforms are de-regulated in tumour angiogenesis, what are their control mechanisms (eg splice factors involved) and how can they be manipulated therapeutically.

If you have questions about the project, please contact the lead supervisor: Dr Seb Oltean


Funding Notes

This project is self funded. Information about Exeter's current fees can be found here: View Website.

Please note:
There are additional costs associated with this project: approximately £7000 without animal work; £10000 with animal work. For more information please contact the lead supervisor.

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