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Stabilising biopolymer based hydrogels for delivery of actives


Project Description

The Centre for Sustainable Chemical Technologies (CSCT) at the University of Bath has now launched a new joint PhD programme with Monash University, Australia. The Bath Monash Global PhD Programme will have its first intake in October this year.

This project is one of a number that are in competition for up to four funded studentships. More details are available here: http://www.csct.ac.uk/study-with-us/.

Home institution: University of Bath
Supervisors at Bath: Professor Janet Scott (lead) and Professor Karen Edler
Supervisors at Monash: Professor Antonio Patti and Professor Gil Garnier

Hydrogels, polymer networks extensively swollen with water, are used in a vast range of applications, including: the production of cell scaffolds for tissue engineering, delivery of drugs and agrochemical active compounds, as thickening agents in foods and formulated products, and as superabsorbent polymers, either for sequestration of liquids, e.g. in diapers, or controlled delivery of liquids, e.g. as water reservoirs in agriculture.

Many synthetic polymer hydrogels are known, but naturally derived particulate hydrogels have recently garnered much attention and combinations of soluble biopolymer and biopolymer nanoparticles offer opportunities for the development of renewably derived and biodegradable hydrogel systems. In all cases biodegradability must be tested (not assumed) and bioresorbability can offer opportunities in medical applications such as tissue scaffolds and slow release of active pharmaceutical ingredients (APIs). Biodegradable hydrogels, which are nonetheless persistent enough to deliver the benefit required, are useful as water retaining soil amendments in agriculture, particularly in climates where rainfall can be intermittent and/or low, such as Australia.

While many examples of hydrogels formed from natural biopolymers, e.g. bacterial cellulose, biopolymer particles, e.g. oxidized cellulose nanofibrils (OCNF), or soluble biopolymers, e.g. chitosan and alginate, exist, crosslinking strategies frequently rely on use of deleterious agents such as gluteraldehyde (which is even used a sterilant as it kills cells, including bacteria). New, more human- and enviro-friendly hydrogel materials and crosslinking strategies are needed.

In this project a range of crosslinking strategies will be evaluated, including use of non-toxic crosslinkers, e.g. poly-acids derived from natural sources or fermentation that can be induced to form reactive anhydrides in situ, and enzymatically mediated crosslinking, including of modified biopolymer particles and soluble polymers (at the University of Bath). The materials prepared will be characterized at both ‘molecular’ and ‘materials’ levels, and network form and porosity examined by a combination of advanced techniques including in collaboration with colleagues in Brazil, who are developing new NMR based methods for evaluation of porosity, swelling and gelation.

To test the materials in application, formation of hydrogel based soil amendments that provide the dual functions of water retention/slow release during times of drought and delivery of actives, including fertilisers and growth enhancers, will be examined. Trials of these materials will be conducted at Monash University and will include ‘real’ tests on growing plants and evaluation of these materials in formulations to improve existing novel fertilizer preparations. Drying and rehydration will also be examined as this is key to use in large scale applications. Opportunities in tissue engineering will not be ignored, but will form part of a separate PhD project, providing exciting collaborative materials testing opportunities.

The expertise of the two centres is entirely complementary, yet not overlapping, making this a very balanced partnership and providing a PhD student with access to knowledge and skills that could not be gained at a single institution.

Applications:

We invite applications from Science and Engineering graduates who have, or expect to obtain, a first or upper second class degree and have a strong interest in Sustainable Chemical Technologies.

You may express an interest in up to three projects in order of preference. See the CSCT website for more information: http://www.csct.ac.uk/study-with-us.

Please submit your application to the Home institution of your preferred project. However, please note that you are applying for a joint PhD programme and applications will be processed as such.

If this is your preferred project, apply using Bath’s online application form:
https://samis.bath.ac.uk/urd/sits.urd/run/siw_ipp_lgn.login?process=siw_ipp_app&code1=RDUCH-MO01&code2=0001.
Please quote ‘Bath Monash PhD studentship’ in the Finance section and the lead supervisor(s)’ name(s) and project title(s) in the ‘Your research interests’ section. More information on applying to Bath may be found here:
https://www.bath.ac.uk/guides/how-to-apply-for-doctoral-study/

If the Home institution of your preferred project is Monash, apply here: https://docs.google.com/forms/d/e/1FAIpQLSd4RT7A62PF6DSqLQLNFBUltFIHv1Cf12oI_CKY_Op8-k3XPw/viewform

Enquiries about the application process should be sent to .

Funding Notes

Bath Monash PhD studentships include tuition fee sponsorship and a living allowance (stipend) for the course duration (up to 42 months maximum). Note, however, that studentships for Bath-based projects will provide cover for UK/EU tuition fees ONLY. Non-Australian nationals studying in Australia will be required to pay their own Overseas Student Health Cover (OSHC).

Additional and suitably qualified applicants who can access a scholarship/studentship from other sources will be also considered.

References

1. J. C. Courtenay, M. A. Johns, F. Galembeck, C. Deneke, E. M. Lanzoni, C. A. Costa, J. L. Scott, R. I. Sharma, Surface Modified Cellulose Scaffolds for Tissue Engineering, Cellulose, 2017, 24, 253-267; 125. M. A. Johns, Y. H. Bae, F. E. G. Guimarães, E. Lanzoni, C. Costa, P. Murray, C. F Deneke, F. Galembeck, J. L Scott, R. I. Sharma, Predicting ligand-free cell attachment on next generation cellulose-chitosan hydrogels, ACS Omega, 2018, 3, 937–945.

2. J. C. Courtenay, J. G. Filgueris, E. Riberio de Azevêdo, Y. Jin, K. J. Edler, R. I. Sharma and J. L. Scott, Mechanically robust cationic cellulose nanofibril 3D scaffolds with tuneable biomimetic porosity for cell culture, J Mater. Chem B, 2019, 7, 53-64.

How good is research at University of Bath in Chemistry?

FTE Category A staff submitted: 33.10

Research output data provided by the Research Excellence Framework (REF)

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