Staphylococcus aureus Infection Dynamics
S. aureus is a major human pathogen of increasing importance due to the spread of antibiotic resistance. It can cause a wide range of diseases, from superficial skin infections to life threatening endocarditis and septicaemia. Do be so adaptable requires a repertoire of virulence determinants and the ability to evade the human immune system. We have begun to map how S. aureus causes disease from its outset to completion. This has revealed a complex and dynamic interaction with our resident microflora as well as our immune cells.
The project will take an interdisciplinary approach to understand how S. aureus can cause disease and the effect of interventions including vaccination and antibiotics. The research will include in vivo work, in particular the use of the zebrafish embryo model of infection. This model allows evaluation of host:pathogen interaction in a living host, whose transparency permits visualisation of infection in real time at the cellular level.
Science Graduate School
As a PhD student in one of the science departments at the University of Sheffield, you’ll be part of the Science Graduate School – a community of postgraduate researchers working across biology, chemistry, physics, mathematics and psychology. You’ll get access to training opportunities designed to support your career development by helping you gain professional skills that are essential in all areas of science. You’ll be able to learn how to recognise good research and research behaviour, improve your communication abilities and experience technologies that are used in academia, industry and many related careers. Visit www.sheffield.ac.uk/sgs to learn more.
First class or upper second 2(i) in a relevant subject. To formally apply for a PhD position, you must complete the University's application form using the following link: http://www.sheffield.ac.uk/postgraduate/research/apply/applying
*All applicants should ensure that both references are uploaded onto their application as a decision will be unable to be made without this information*.
How good is research at University of Sheffield in Biological Sciences?
FTE Category A staff submitted: 44.90
Research output data provided by the Research Excellence Framework (REF)
Click here to see the results for all UK universities