About the Project
In this PhD, IPD will be collected from eligible RCTs of add-on treatment in patients with refractory epilepsy. Statistical issues for the analysis of these trials will be explored and a network meta-analysis undertaken using the most efficient and statistically reliable methods. It is anticipated that the characteristics of trials and their participants will have changed over time due to the changing global nature of epilepsy research, the widening population of available AEDs, and changes in the classification and management of epilepsy. Patients within, and across, trials will also differ in the adjunctive AEDs taken alongside the experimental add-on AED or placebo. Such differences are likely to impact upon the underlying assumptions made in a network meta-analysis and the value of having IPD to thoroughly explore such issues will be fully exploited. The research would be completed with support from the Cochrane Epilepsy Group.
You should have, or expect to hold a BSc in Statistics or relevant discipline. An MSc in Statistics or relevant discipline is desirable.
*Please note the English Language Requirement for EU Students is an IELTS score of 6.5 with no band score lower than 5.5.
To apply please email your CV and cover letter to Rachael Kelly via [Email Address Removed].
For application enquires please contact Professor Catrin Tudur Smith [Email Address Removed].
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