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Statistical methods for economic evaluation alongside stepped wedge cluster randomised controlled trial


   Wolfson Institute of Population Health

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  Dr Yan Feng  No more applications being accepted  Competition Funded PhD Project (Students Worldwide)

About the Project

Background to the project

Cluster randomised controlled trials are widely used in health service evaluation. A common approach is a parallel design where clusters in control and intervention arms receive their respective intervention throughout the trial period. An alternative is the stepped wedge design where all clusters are first allocated to the control arm followed by exposing to intervention sequentially until all clusters are exposed. The stepped wedge design has been increasingly applied in recent years.

In many countries, decision makers need to judge both the scientific value (clinical effectiveness) and social value (cost effectiveness) of a treatment. Economic evaluations are commonly performed alongside clinical trials to produce evidence of cost-effectiveness. Methodology for economic evaluation conducted alongside parallel cluster randomised trials has developed in recent years. Evidence of cost-effectiveness from stepped wedge trials began to emerge from 2014, but a recent review of 54 protocols and trial reports found only 16 reported methods appropriate to the stepped wedge design (Lung, Si, Hooper & Di Tanna, DOI:10.1007/s40273-020-00963-x). With the rapid growth in stepped wedge trials, there is an urgent need to improve methods and disseminate them in order to increase their adoption. 

What the studentship will encompass:

The project aims to identify appropriate statistical methods for economic evaluation alongside stepped wedge trials. It includes three objectives: 

(1)  To review and critically assess methodological work.

(2)  Building on existing work, to compare methodological approaches e.g. using simulation, and potentially propose and apply novel methods such as hierarchical Bayesian models.

(3)  To facilitate their use, for instance by publishing a tutorial and practical guidance.

(4)  To develop a checklist for appropriate statistical methods.

The student will work closely with both supervisors at QMUL. Professor Hooper is a world leading expert on the design and analysis of stepped wedge trials. Dr Feng is a health economist with experience in conducting economic evaluation alongside parallel cluster randomised trials: she will contribute to all three objectives of the project, and provide support to the student on a day-to-day basis. Professor Di Tanna is the lead author of the published review of economic evaluation in stepped wedge trials and is conducting ongoing research in this area, and will input to the project as an external advisor.

The studentship will be embedded within the Pragmatic Clinical Trials Unit (PCTU), a UKCRC-registered trials unit working at the forefront of the science and execution of pragmatic clinical trials. PCTU has an international reputation for its research on stepped wedge trial design, and a thriving health economics group with strong methodological interests.

Trials run in collaboration with PCTU all closely involve patients and the public, and the Wolfson Institute of Population Health, which hosts PCTU, has a Public Advisory Panel representing the social, cultural and ethnic diversity of East London. The student will have opportunities to explore how patient and public involvement could add value to their project. 

Candidates should have a good first degree in a quantitative subject such as statistics, mathematics, economics, epidemiology. A Master’s degree in a relevant discipline such as health economics, applied statistics is preferred but not compulsory. Candidates should able to use a code based statistical software package such as Stata or R.

HOW TO APPLY

You are applying for a PhD studentship from the MRC TMRP DTP. A list of potential projects and the application form is available online at:

http://www.methodologyhubs.mrc.ac.uk/about/tmrp-doctoral-training-partnership/

Please complete the form fully. Incomplete forms will not be considered. CVs will not be accepted for this scheme.

Please apply giving details for your first choice project. You can provide details of up to two other TMRP DTP projects you may be interested in at section B of the application form.

Before making an application, applicants should contact the project primary supervisor to find out more about the project and to discuss their interests in the research.

The deadline for applications is 4pm (GMT) 18 February 2022. Late applications will not be considered.

Completed application forms must be returned to: [Email Address Removed]

Informal enquiries may be made to [Email Address Removed]


Funding Notes

Studentships are funded by the Medical Research Council (MRC) for 3 years. Funding will cover tuition fees at the UK rate only, a Research Training and Support Grant (RTSG) and stipend (stipend to include London Weighting where appropriate). We aim to support the most outstanding applicants from outside the UK and are able to offer a limited number of bursaries that will enable full studentships to be awarded to international applicants. These full studentships will only be awarded to exceptional quality candidates, due to the competitive nature of this scheme.
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